Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol

Inclusion Criteria: 1. Aged 18-65 years old, both gender; 2. Patients with acute or chronic suppurative otitis media, need to be treated partially by antimicrobial agents; 3. Written informed consent form. Exclusion Criteria: 1. Allergic to quinolones antibiotics or severe allergic constitution; 2. Not able to collect otorrhea during the trial; 3. High severity with the need of combined antibiotics treatment; 4. Induced by pathogens, e.g.: fungus, virus (myringitis bullosa); 5. Combined otitis externa (e.g.: ear cellulitis, mumps), intracranial or extracranial complication (meningitis, cerebral abscess, thrombophlebitis of sigmoid sinus, Bezold's abscess, ear subperiosteal abscess); 6. Severe disease of cerebral, cardiopulmonary, renal hepatic, circulatory system; 7. Life-threatening disease, e.g.: malignant tumor or AIDS. 8. Renal hepatic dysfunction (ALT, AST ≥ 1.5 times of normal maximum level, Cr \> normal maximum level); 9. Confirmed or suspected of alcohol/drug abuse record; 10. Neurological or psychiatric disease leading to inability of cooperation or not willing to follow the protocol or instruction; 11. Feminine patients who are in gestational, lactation period or having a birth plan in short-term; 12. Enrolled into other clinical trial in the past 3 months; 13. Not suitable for this trial according to investigator's judgment;