Hedonic Perception and Brain Activity Response to Meal

Hospital Universitari Vall d'Hebron Research Institute80 enrolled

Overview

The purpose of this study is to determine the relationship between brain activity and the perception of subjective hedonic sensations in response to a meal using functional MRI.

Functional MRI brain imaging will be performed in patients with functional dyspepsia and healthy controls in basal conditions and after a palatable test meal. During the study, the cognitive response and the hedonic dimension will be measured using 10 score scales.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Dyspepsia

Interventions

Functional brain MRIDEVICE

Functional brain MRI before and after test meal ingestion

A warm ham and cheese sandwich and a 200 ml fruit juiceDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 18 and 80 yrs 2. Body mass index between 18-30 Kg/m2 3. Right-handed Exclusion Criteria: 1. Subjects with clinical history of eating-disorders 2. Subjects with clinical history of significant head-trauma 3. Subjects with known serious illness: clinically significant cardiac, vascular, liver, pulmonary, or psychiatric disorders (as evaluated by the Investigator). 4. Subjects with a known history of alcohol or drug abuse in the previous 6 months. 5. Subjects using medications with SNS effects that cannot be discontinued, such as: antidepressants, pregabalin, gabapentin. 6. Women that are pregnant or that are breast-feeding. 7. Claustrophobia

Locations (1)

Vall d'Hebron Research Institute

Barcelona, Spain

Outcomes

Primary Outcomes

Change in activity in specific brain regions measured by functional MRI

To determine the brain response to a meal in patients with functional dyspepsia and healthy subjects.

Time frame: 3 hours

Cognitive and hedonic perception measured on 10 score scales (composite outcome)

To determine the cognitive and hedonic response to a meal in patients with functional dyspepsia and healthy subjects.

Time frame: 3 hours

Secondary Outcomes

Metabolomic response measured in serum by NMR spectroscopy

To identify the metabolomic substrate of the cognitive and brain responses to a meal.

Time frame: 3 hours

Data from ClinicalTrials.gov

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