Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

University Hospital Ostrava60 enrolled

Overview

The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).

Recurrent respiratory papillomatosis (RRP) is a chronic viral disease, which affects children and adults as well. It is characterised by grow of squamous cell tumours on mucosa of aerodigestive tract, with predilection for the larynx. The disease is caused by the human papillomavirus (HPV). However, in contrast to the low incidence of RRP, HPV prevalence is common. It is indicated that other factors may contribute to the pathogenesis of RRP. One such factor might be extraesophageal reflux (EER). We investigated whether patients with RRP suffer more often from EER.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Recurrent Respiratory Papillomatosis Extra Oesophageal Reflux Laryngeal Cyst

Interventions

Surgical collection of histology specimenPROCEDURE

Collection of a histology specimen from the vocal cords and rear laryngeal commissure

Performance of immunohistochemical analysisPROCEDURE

Immunohistochemical analysis - presence of pepsin, HPV 6 and 11, HSV 2 and chlamydia trachomasis

Eligibility

Sex: ALLMin age: 1 YearMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 1-75 years * cooperating patients with laryngeal papillomatosis * patients tolerating impedance probe * signed informed consent, consent with the examinations * control group of patients with a cyst or vocal cord polyp (reflux finding score 0-2) and/or patients indicated to augmentation, medialization or lateralization of the vocal cords Exclusion Criteria: * patients non-tolerating impedance catheter * patients who do not understand Czech language * patients who do not proclaim consent with enrolment into the study * patients who do not proclaim consent with the planned examinations * patients after surgical treatment of tumour of the swallowing or respiratory tract

Locations (1)

University Hospital Ostrava

Ostrava-Poruba, Czech Republic, Czechia

Outcomes

Primary Outcomes

Occurrence of EER (percentage)

The occurrence of extra oesophageal reflux will be assessed in both study groups.

Time frame: 36 months

Secondary Outcomes

Presence of pepsin

The presence of pepsin (yes-no) will be assessed in both study groups.

Time frame: 36 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.