AVAD: Asthma With Small Airways Dysfunction

General Inclusion Criteria: * man or woman * age ≥ 18 years * asthma * inform consent signed * affiliated to health insurance Specific inclusion criteria : asthma with proximal airways obstruction GROUP * Maximal Voluntary Ventilation (MMV)\<80% * MMV / Forced Vital Capacity (FVC)≤70% * Carbon Monoxide Transfer Coefficient (KcO)\>80% Specific inclusion criteria : asthma with small airways dysfunction GROUP * Maximal Voluntary Ventilation (MMV)≥80% * MMV / Vital Capacity(VC)\>70% * Carbon Monoxide Transfer Coefficient (KcO)\>80% General Exclusion Criteria: * pregnant woman or breastfeeding * patient participating to other biomedical research * patient who have participated to other biomedical research within the past 3 months * patient refusing to sign the inform consent Specific exclusion criteria : * Patient who stopped smoking since less than 12 months * Pathological state related to obstructive distal airway damage * Broncho-pulmonary infectious disease within the past 4 weeks * Solid tumor curated by chemotherapy or chest radiotherapy * Chronic respiratory disease * Asthma exacerbation within the past 3 months * Oral or systemic corticotherapy within the past 3 months