The aim of the study is to assess the peripheral endothelial function in adult COPD (chronic obstructive pulmonary disease) patients and the relationship between the peripheral endothelial function and the pulmonary function.
The primary criteria is the peripheral endothelial function that will be assessed by the measure of flow-mediated dilation (reactive hyperemia-peripheral artery tone index). The pulmonary function will be assessed by the measures of the FEV1 (forced expiratory volume in one second), the forced vital capacity (FVC) and the expiratory flow between 25% and 75% (FEF25-75%). The relationship between these parameters of the pulmonary function and the peripheral endothelial function will be analyzed. In addition, a relationship between peripheral endothelial function and the severity of COPD (classification according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2010 and GOLD 2011 and the COPD assessment test, the cardiovascular risk factors (SCORE INdex) and the smoker status will be also assessed.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
137
measure of peripheral endothelial function by the reactive hyperemia-peripheral artery tone index with a specific device (EndoPAT®)
Hôpital Saint-Antoine
Paris, France
Hôpital Foch
Suresnes, France
measure of reactive hyperemia-peripheral artery tone index
measure of reactive hyperemia-peripheral artery tone index
Time frame: Day 1
measure of Forced expiratory flow in one second
measure of Forced expiratory flow in one second
Time frame: day 1
measure of forced vital capacity
measure of forced vital capacity
Time frame: day 1
measure of expiratory flow between 25% and 75% (FEF25-75%).
measure of expiratory flow between 25% and 75% (FEF25-75%).
Time frame: day 1
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