This study aims at evaluating the feasibility of CT myocardial perfusion imaging in daily clinical practice and compare it to SPECT perfusion imaging in order to assess sensitivity and specifity of CT myocardial perfusion imaging compared to SPECT.
If after the clinically indicated CCTA a myocardial perfusion examination is indicated, first a single ultra low dose CT scan will be performed to look for late enhancement of potentially scarred myocardium. Together with the contrast agent co-injection of the clinically indicated tracer 99mTc-Tetrofosmin will be performed for later scintigraphic perfusion evaluation. After stress perfusion imaging CT rest perfusion imaging will be performed in a similar fashion. After acquisition of CT rest perfusion images scintigraphic stress and rest image acquisition will be performed as in daily clinical routine with an additional administration of 99mTc-Tetrofosmin resting dose if necessary. CT stress and rest perfusion will be compared to the clinically indicated and well established SPECT examination.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
43
All patients undergo CT-MPI plus SPECT-MPI
Department of Nuclear Medicine, University Hospital Zurich
Zurich, Switzerland
Validation of CT-MPI against SPECT-MPI
Sensitivity and specificity of CT-MPI to diagnose obstructive coronary artery disease using SPECTR-MPI as the standard reference
Time frame: 2 years
Parameters influencing image quality of CT-MPI - Body physique
Correlation between visually assessed image quality of CT-MPI and patient's body mass index
Time frame: 2 years
Parameters influencing image quality of CT-MPI - Heart rate
Correlation between visually assessed image quality of CT-MPI and patient's heart rate during the scan
Time frame: 2 years
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