Pegylated Interferon(Peg-IFN) in Reducing Relapse Rate in Patients After Discontinuation of NUC Therapy

Inclusion Criteria: 1. HBeAg-Negative Chronic Hepatitis B Patients：HBsAg-Positive,HBsAb-Negative,HBeAg-Negative,HBeAb-Positive during screening period and before NA treatment 2. NUC monotherapy (including adefovir and entecavir) for more than 2.5 years,and reached stopping rule in 《Chinese chronic hepatitis B prevention and treatment guidelines》(2010):the patients who achieved undetectable HBV DNA (\<300 copies/mL) with normal alanine aminotransferase (ALT) and the consolidation therapy reached 1.5 years ,total course of the treatment reached 2.5 years can stop NUC therapy 3. Willing to stop the drug, and signed a written informed consent Exclusion Criteria: 1. HBsAb positive in screening period 2. Compensated or Decompensated liver cirrhosis:with history of cirrhosis before NUC treatment or Child-Pugh score ≥ 5 or Complications of liver cirrhosis such as ascites, hepatic encephalopathy, esophageal gastric varices bleeding 3. Hypersensitivity to interferon(IFN) or its active substance, and ineligible to IFN 4. A history of immunoregulation drug therapy within one year before entry including IFN and so on. 5. Coinfection with HAV、HCV、HDV、HEV 、HIV or with Other chronic liver diseases such as Alcoholic Liver Disease,Inherited Metabolic Liver Disease,Drug induced Liver Disease and nonalcoholic fatty liver 6. Autoimmune disease including Autoimmune hepatitis and Psoriasis and so on. 7. Hepatocellular carcinoma(HCC) or alpha feto protein(AFP) levels more than 100 ng/ml and Hepatic malignant potential of Imaging examination or AFP levels more than 100 ng/ml for 3 months 8. A neutrophil count of less than 1500 per cubic millimeter or a platelet count of less than 90,000 per cubic millimeter 9. A serum creatinine level that was more than 1.5 times the upper limit of the normal range 10. With other malignant tumors(exclude the cured ones) 11. Severe organ dysfunction 12. With severe psychiatric condition or nervous disease such as epilepsy, depression, mania, epilepsy, schizophrenia and so on 13. Uncontrolled diabetes, hypertension or thyroid disease 14. Pregnant women and lactating women or patients with pregnancy plans and not willing to use contraception during the study period 15. Participate in other clinical studies at the same time 16. Patients unsuitable for the research