A Phase I Dose Escalation Study of the Safety and Pharmacokinetics of LAM-002A In Patients With Non-Hodgkin's Lymphoma

Inclusion Criteria: 1. Able to understand and comply with the protocol requirements and has signed the informed consent document. 2. Confirmed diagnosis of B-cell Non-Hodgkin's lymphoma limited to follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), primary mediastinal B-cell lymphoma (PMBL), or chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that has progressed and for which standard curative measures do not exist or are no longer effective. Prior therapy must have included a rituximab-based regimen. 3. Patients with DLBCL: Cancer progression after transplant, or be unwilling, unable or not an appropriate candidate for an autologous stem cell or bone marrow transplant 4. Radiographically measurable lymphadenopathy or extranodal lymphoid malignancy (defined as the presence of 1 or more lesions that measure at least 2.0 cm in the longest dimension (as assessed radiographically) 5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or less. 6. Adequate organ and marrow function. 7. Able to swallow oral capsules without difficulty. 8. Acceptable birth control. 9. Women of childbearing potential : negative pregnancy test 10. Adequate archival or fresh tumor tissue (from biopsy, bone marrow, or peripheral blood) for analysis of potential predictive biomarkers. Exclusion Criteria: 1. Patients with central nervous system (CNS) lymphoma are not eligible for the trial unless the disease had been treated and the subject remains without symptoms with no active CNS lymphoma. 2. Not recovered from toxicity due to all prior therapies. 3. Other uncontrolled significant illness. 4. History of malabsorption or other gastrointestinal (GI) disease that may significantly alter the absorption of LAM-002A 5. Major surgery within 28 days prior to first dose of study drug. 6. Past history of tuberculosis (TB) or active infection with TB, human immunodeficiency virus (HIV), hepatitis B or hepatitis C. 7. Lactation or breast feeding. 8. Unable or unwilling to abide by the study protocol or cooperate fully with the Investigator or designee. This is a shortened list and additional criteria may apply.