Effects of the Mechanical Peripheral Stimulation for Parkinson's Disease Rehabilitation

Federal University of Health Science of Porto Alegre28 enrolled

Overview

The purpose of this study is to evaluate safety and effectiveness of the peripheral mechanical stimulation of the feet on gait variables, clinical status, risk of falls, BDNF levels, immunological profile and brain functional connectivity changes in patients with Parkinson's disease.

Patients will be submitted to 8 sessions of peripheral mechanical stimulation of the feet or sham stimulation along 4 weeks. Evaluations will be performed before and after the first session, after the forth and the eighth session.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Parkinson's Disease

Interventions

Mechanical Peripheral Stimulation (GONDOLA)DEVICE

Eligibility

Sex: ALLMin age: 50 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of idiopathic Parkinson's disease based on clinical criteria, dopamine transporter (DaT) scans and/or magnetic resonance imaging; * Able to walk 25 feet unassisted or with minimal assistance; * Presenting freezing of gait; * Aged between 50-85 years; * Minimum score of 20 in the Mini Mental State Examination (MMSE); Exclusion Criteria: * Secondary musculoskeletal disorder involving the lower limb, as chondral injuries, ligament and ankle sprains which may impede the realization of the gait by pain or motion disability; * Peripheral neuropathy; * Not attending all the treatment; * Absolute contraindications for fMRI (just for fMRI examination); * Presence of deep brain stimulation;

Locations (1)

Universidade Federal de Ciências da Saúde de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil