Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.
PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
16
Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.
Only Conventional Flap Surgery treatment the bone loss limitedly.
Alper KIZILDAĞ
Denizli, Denizli, Turkey (Türkiye)
Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly
Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper.
Time frame: 4 weeks
Alteration of Clinical Attachment Level
Change from baseline Clinical Attachment Levels at 6 months were measured with periodontal probe.
Time frame: 6 month
Alteration of Periodontal Pocket Depth
Change from baseline Pocket Depth at 6 months were measured with periodontal probe.
Time frame: 6 month
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