The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis

University of California, Davis20 enrolled

Overview

The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate the effects of different moisturizers on the skin barrier of subjects with and without atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin pH, decrease the skin hydration, and increase skin water loss in all study subjects. Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest water to oil ratio will result in improved skin barrier function. Furthermore, the investigators believe there will be a greater improvement in patients with atopic dermatitis.

The study has two main parts. Subjects in both groups will have one forearm in a dilute bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be measured using different painless devices. The second part of the study involves application of 4 various moisturizers. The change in skin will be measured over a period of time using the non-invasive devices.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Atopic Dermatitis

Interventions

Bleach Bath and MoisturizersOTHER

All subjects will have one forearm in a bleach bath and the other forearm in a water bath for 10 minutes. Following the bath, skin barrier function will be evaluated. Secondly, moisturizers will be applied to the arms and the skin barrier will be evaluated overtime.

Eligibility

Sex: ALLMin age: 8 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 8 years to 65 years * Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC Davis * Subject/parents/legal guardians able to read and comprehend the study procedure and consent forms. Exclusion Criteria: * Those who are pregnant, prisoners, or cognitively impaired * Those who do not fit the inclusion criteria

Locations (1)

UC Davis Department of Dermatology

Sacramento, California, United States

Outcomes

Primary Outcomes

Change in transepidermal water loss post-bath immersion

Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in transepidermal water loss after 10 minutes of bath immersion.

Time frame: 10 minutes post-bath immersion

Secondary Outcomes

Change in transepidermal water loss after moisturizer application

Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in transepidermal water loss to 60 minutes post-application..

Time frame: up to 60 minutes post-moisturizer application

Change in skin hydration after moisturizer application

Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin hydration up to 60 minutes post-application..

Time frame: up to 60 minutes post-moisturizer application

Change in skin pH after moisturizer application

Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin pH up to 60 minutes post-application..

Time frame: up to 60 minutes post-moisturizer application

Change in skin hydration post-bath immersion

Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin hydration after 10 minutes of bath immersion.

Time frame: 10 minutes post-bath immersion

Change in skin pH post-bath immersion

Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin pH after 10 minutes of bath immersion.

Time frame: 10 minutes post-bath immersion

Data from ClinicalTrials.gov

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