Treatment of the Symptomatic Sacral Perineurial Cysts

Inclusion Criteria: * 1\. Diagnosed with symptomatic sacral perineurial cysts(e.g., lumbosacral or perineal pain, fecal or urinary functions change, sexual function change, lower limb radiation pain, muscle abate, paresthesia, etc) * 2\. Visual analog scale more than or equal to 4 * 3\. Signed the informed consent * 4\. Years, range 18-60 * 5\. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores \< 50 * 6\. No Congenital,Mental and other Nervous system diseases * 7\. No Serious Cardiac,Pulmonary,Hepatic and Nephritic disease * 8\. No history of drug allergy * 9\. No pain(including dysmenorrhea) or drug use (e.g., antipyretics,sleeping pills) within the last month * 10\. MRI finding of sacral perineurial cysts, but without any clinical symptoms, included in the negative control group * 11\. MRI finding healthy volunteers don't have sacral perineurial cysts, included in the negative control groupblank control group Exclusion Criteria: * 1\. Patients with lumbar common diseases(e.g., Lumbar disc, Lumbar spinal stenosis, Lumbar slippage, etc) * 2\. Researchers think that Patients with disease may be interference results(e.g., Spinal deformity, spine fracture, ankylosing spondylitis, spinal tuberculosis and spinal infection, spinal tumor, pelvic inflammatory disease and other disease of department of gynaecology, etc) * 3\. Patients with other nervous system diseases(e.g., cerebral tumor, neurinoma, trigeminal neuralgia,etc) * 4\. Patients with Magnetic resonance imaging contraindication ,including claustrophobic syndrome patients * 5\. Patients with recent (less than 3 years) use chemical drugs or have obvious psychological problems * 6\. In the past 2 months involved in other drugs or devices clinical trials