Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

Hôpital Armand Trousseau12 enrolled

Overview

A standardized tetanic stimulation is applied to patients under propofol-remifentanil TCI, in a cross-over fashion, at two different levels of anesthesia monitored by the BIS: BIS 25 and BIS 55. Remifentanil target remains constant during the whole study period (1 ng/ml). Pupillary reflex dilation is recorded after each stimulation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Pain

Interventions

RemifentanilDRUG

propofolDRUG

TCIDEVICE

Tetanic stimulationPROCEDURE

Eligibility

Sex: ALLMin age: 10 YearsMax age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA 1-2 * scheduled for an idiopathic scoliosis surgical correction Exclusion Criteria: * Ophtalmologic pathology * Neurologic or muscular pathology * Metabolic pathology * Chronic pain

Locations (1)

Departement d'anesthesie Hopital Armand Trousseau

Paris, France

Outcomes

Primary Outcomes

Post-stimulation Pupillary reflex dilation

percentage of dilation compared to pre-stimulation pupillary diameter

Time frame: 30 seconds

Data from ClinicalTrials.gov

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