Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal

University of Turin, Italy14 enrolled

Overview

This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows reduction of tidal volume and plateau pressure. Systemic Inflammatory Response and Safety Variables will also be analysed.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Kidney Injury

Interventions

RRT plus ECCO2RDEVICE

Patients with acute kidney injury will be treated with Renal replacement therapy associated to extracorporeal carbon dioxide removal in a single treatment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with acute kidney injury (AKI) requiring renal-replacement therapy and mechanical ventilation of duration ≥ 48 hours Exclusion Criteria: * little chance of survival at 24 h (according to clinical judgment), pregnancy, mechanical ventilation with expected duration lower than 48h, age under 18 and over 90

Locations (1)

Azienda Ospedaliera Città della Salute e della Scienza di Torino

Turin, Italy

Outcomes

Primary Outcomes

Achievement of tidal volume reduction to 4 mL/kg while maintaining pH and PaCO2 to ± 20% of baseline values

Time frame: 72 hours

Secondary Outcomes

Evaluation of inflammatory mediators release in plasma samples of patients

Plasma Concentrations of interleukin 6, interleukin 8, interleukin 1 beta, tumor necrosis factor alpha

Time frame: 72 hours

Assessment of the changes in pH

Time frame: 72 hours

Assessment of the changes in PaCO2

Time frame: 72 hours

Assessment of the changes in PaO2

Time frame: 72 hours

Data from ClinicalTrials.gov

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