This study will attempt to use a type of non-invasive brain stimulation technology during sleep to improve measures of sleep quality and memory in young healthy students and older adults. The type of brain stimulation is called transcranial direct current stimulation (tDCS), which uses small currents of electricity to increase or decrease the activity of specific areas of the brain.
Transcranial direct current stimulation (tDCS) is a safe, non-invasive, and inexpensive brain stimulation modality that has been shown to have the ability to modulate both cortical and deep brain structure activity. This technique has undergone a significant amount of investigation in varied neuropsychiatric populations and interest in this technique has increased dramatically as of late. Some researchers have studied the effects of this modality on sleep as well as memory with promising results. One such study demonstrated that by using bilateral tDCS with a pattern of stimulation in the delta frequency range (0-3 Hz) delivered during slow wave sleep, that it is possible to increase delta power during slow wave sleep, as well as improve sleep efficiency. In addition to showing that it is possible to enhance slow waves, it was also demonstrated that this increase was associated with an improvement of a measure of declarative memory consolidation (one of the theorized functions of slow wave sleep). Enhancing memory function in a normal healthy group raises the possibility that it would also be possible to enhance memory in clinical populations who would benefit from such an intervention. The investigators propose to test this intervention for replication in a similar cohort.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
14
tDCS is a type of brain stimulation that uses low current applied directly over the scalp to increase, or decrease cortical activity under the stimulating electrodes. tDCS applied bi-frontally using Chattanooga Ionto™ Iontophoresis System - Phoresor. A square wave will be delivered at 0.75 Hz for five blocks of five minutes each with one minute inter-train interval. Stimulation will be applied following 8 epochs of consecutive stage 2 or deeper sleep.
tDCS device connected and tested, but not turned on during the night. This has been found to be an effective sham in other studies using this technique.
Medical University of South Carolina
Charleston, South Carolina, United States
Declarative memory assessed by paired word association test
Prior to and directly after a night of sleep we will assess declarative memory using a paired word association tests. In the pre-sleep assessment there will be a learning phase where the word list will be presented serially, until 60% of the words are retained. In the post sleep assessment the word list will be given again once. The outcome measure is the change in words retained between pre and post sleep assessments. Subsequently the followup interval is approximately 8-9 hours with baseline before bedtime, and follow up assessment once the patient is awoken.
Time frame: Pre sleep/intervention, and post sleep/intervention
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