Neoadjuvant Propanolol in Breast Cancer

Inclusion Criteria: * Ages 18- 65 * diagnosis of stage I-III breast cancer , confirmed by a core biopsy * Planning to undergo definitive surgery including mastectomy or breast conserving surgery * Systolic blood pressure must be \>100 mmHg but no more than 140 mmHg and/or diastolic \> 60 mmHg and no more than 95 mmHg. * normal baseline EKG Exclusion criteria: * Pregnancy; potential subjects of female bearing age will have to complete a pregnancy test during screening to ensure that they are not pregnant. Potential patients who are post-menopausal must have confirmed one year without menstrual cycle. * Free of major medical illnesses including: * Uncontrolled Diabetes (HbA1c of ≤ 8 if previously tested) * Uncontrolled hypertension: BP \>systolic 140/ diastolic \> 95 * Cardiac diseases (history of cardiac valve disease, coronary artery disease, congestive heart failure, A-V block, peripheral vascular disease, any cardiac arrhythmia/bradycardia) with the exception of the diagnosed cancer. * Histories of asthma, bronchospastic disease, or obstructive pulmonary disease * Previously diagnosed thyrotoxicosis * Severe allergic reactions to medications which are included in the beta blocker family * Previously or currently treated with a beta adrenergic receptor antagonist * Patients with locally advanced or inflammatory breast cancer not amenable to surgical resection * Patients taking any of the following medications will be excluded: * Drugs that are categorized as digitalis glycosides, beta-blockers and calcium channel blockers, ACE inhibitors and alpha blockers * Amiodarone * Cimetidine * Ciprofloxacin * Delavudin * Dobutamine * Ethanol * Fluconazole * Fluoxetine * Fluvoxamine * Haloperidol * Imipramine * Isoniazid * Isoproterenol * Luvoxamine * Paroxetine * Phenytoin * Phenobarbital. * Propafenone. * Quinidine * Reserpine * Rifampin * Ritonavir * Rizatriptan. * Tenioposide * Theophylline * Thyroxine * Tolbutamide. * Warfarin * Zileuton * Zolmitriptan