A Prospective, Longitudinal Study of Endothelial Function in HIV/HCV Coinfected Subjects

Inclusion Criteria 1. Men and women ≥ 18 years 2. Hepatitis C negative or chronic hepatitis C infection 3. Chronic HIV infection 4. CD4+ T-cell count \> 200 cells/mm3 5. Plasma HIV-1 RNA \< 50 copies/mL 6. On continuous and stable ART for at least 12 weeks 7. Ability and willingness to provide written informed consent. Exclusion Criteria 1. Known cardiovascular disease 2. Diabetes requiring insulin therapy or hemoglobin A1c \> 8% 3. Inability to conform to requirements for PAT testing 4. Decompensated liver disease 5. Other known causes of significant liver disease 6. Serious illness including acute liver-related disease and malignancy requiring systemic treatment or hospitalization within 12 weeks prior to study entry 7. Presence of active or acute AIDS-defining opportunistic infections (OIs) within 12 weeks prior to study entry 8. History of major organ transplantation with an existing functional graft and on immunosuppressive therapy 9. History of known vascular or autoimmune disease 10. Pregnancy 11. HCV treatment (any approved or investigational agents) within 24 weeks prior to study entry 12. Use of immune-based therapies or systemic corticosteroids within 12 weeks prior to study entry 13. Advanced renal insufficiency as defined by glomerular filtration rate (GFR) \< 30 mL/min/1.73 m2 or treatment by dialysis