Short-term Efficacy of Intravitreal Afilibercept Depending on Subtypes of Polypoidal Choroidal Vasculopathy: Polypoidal Choroidal Neovascularization or Idiopathic Choroidal Vasculopathy

Yeungnam University College of Medicine29 enrolled

Overview

To compare the short-term effect of intravitreal aflibercept injection between two subtypes of polypoidal choroidal vasculopathy

The subjects were classified into two subtypes (type 1 and type 2 polypoidal choroidal vasculopathy) based on the presence or the absence of both of a feeder and a draining vessels on indocyanine green angiography. All received intravitreal injection of aflibercept (2.0 mg) at baseline and months 1, 2 and 4.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Polypoidal Choroidal Vasculopathy

Interventions

AfliberceptDRUG

Total 4 times of intravitreal aflibercept injection was performed

Indocyanine green angiography (intraveonus indocyanine green dye)DRUG

At initial visit, indocyanine green angiography was performed. After 1 month of third Aflibercept injection, indocyanine green angiography was performed to evaluate polyp closure.

Eligibility

Sex: ALLMin age: 45 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. symptomatic typical PCV accompanying branch vascular network involving subfoveal area 2. signed informed consent; and 3. over 6 months follow-up period after enrollment. Exclusion Criteria: 1. retinal diseases other than PCV 2. extrafoveal PCV not involving subfoveal area 3. massive subretinal hemorrhage blocking polypoidal lesion on ICGA 4. severe media opacity such as senile cataract 5. previous history of intravitreal injection 6. previous intraocular surgery history except cataract surgery which was done more than 3 months.

Locations (1)

Yeungnam University College of Medicine

Daegu, South Korea

Outcomes

Primary Outcomes

Regression Rate of Polyp on Indocyanine Green Angiography

Indocyanine green angiography performed initially and at 3 months were used to determine the polyp regression. The definition of complete polyp regression is that the polyps at initial visit disappeared at 3 months on indocyanine green angiography. The partial regression means the polyps remain, but the size decreased \>30%.

Time frame: 3 months

Secondary Outcomes

Best Corrected Visual Acuity

Best corrected visual acuity assessed at baseline, 3 months, and 6 months

Time frame: baseline, 3 months, and 6 monthsc

Data from ClinicalTrials.gov

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