Feasibility and Safety of Functional Performance Testing in Patients Undergoing Hematopoietic Cell Transplantation

Inclusion Criteria: * Patients with MSK histologically confirmed hematologic malignancy * Scheduled for autologous or allogenic HCT at MSKCC * ≥21 years old * ECOG performance status of 0 or 1 * Completion of baseline CPET * Willing to comply with protocol related procedures Exclusion Criteria: * Any of the following absolute contraindications to cardiopulmonary exercise testing * Acute myocardial Infarction (within 3-5 days of any planned study procedures) * Unstable angina * Uncontrolled arrhythmia causing symptoms or hemodynamic compromise * Recurrent syncope * Active endocarditis * Acute myocarditis or pericarditis * Symptomatic severe aortic stenosis * Uncontrolled heart failure * Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures * Thrombosis of lower extremities * Suspected dissecting aneurysm * Uncontrolled asthma * Pulmonary edema * Respiratory failure * Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis) * Presence of any other concurrent, actively treated malignancy; * History of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer); * Room air desaturation at rest ≤85% * Mental impairment leading to inability to cooperate