This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Participants will provide fecal samples pre- and post-operatively.
Analysis of the human microbiome is an attempt to define how changes in the human microbiome are associated with health or disease. Eligible participants scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for appendiceal cancer will provide fecal samples pre- and post-operatively. Investigators will analyze potential changes in the gastrointestinal microbiome and make comparisons to an age-matched healthy sample.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
24
Collection of bio-specimens (fecal sample) at 3 different time points One pre-operative collection, Two post-operative collections
Completion of lifestyle and food questionnaires (2) at each bio-specimen collection timepoint
Mercy Medical Center
Baltimore, Maryland, United States
RECRUITINGDetermine whether the intestinal microbiome of patients with appendiceal tumors with peritoneal carcinomatosis differs from that of a healthy, age-matched cohort
Appendiceal cohort to healthy age-matched cohort
Time frame: 36 months
Compare the gut microbiome of appendiceal tumors by histopathology
Low-grade and high-grade tumors
Time frame: 36 months
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