The investigator will evaluate the influence of colloid administration on postoperative acute kidney injury in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass.
The investigator will randomly divide pediatric patients aged less than 7 years old into crystalloid and colloid groups. Crystalloid group receive only crystalloid, and colloid group receive hydroxyethyl starch (HES, 130/0.4). The maximum volume of HES is limited less than 30 ml/kg. The same transfusion protocol will be applied in both groups. From the day of operation to postoperative 7 days, glomerular filtration rate (GFR), serum creatinin level (Cr) will be checked. Acute kidney injury (AKI) is defined when there is more than 50% increase in Cr when compared to baseline level. The investigator will compare the clinical outcomes including AKI between two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
normal saline administration for volume expansion in hypovolemic status
HES 130/0.4 administration for volume expansion in hypovolemic status
Seoul national university hospital
Seoul, South Korea
Acute Kidney Injury
Time frame: From the day of surgery to postoperative 7 days
Blood loss
Time frame: From the day of surgery to postoperative 7 days
Transfusion amount
Time frame: From the day of surgery to postoperative 7 days
Mechanical ventilation time
Time frame: From the day of surgery to postoperative 7 days
Length of ICU stay
Time frame: From the day of surgery to postoperative 7 days
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