The purpose of this study is to investigate the impact of different nicotine levels in cigarettes with individuals who have ADHD.
The purpose of this study is to examine the effects of very low nicotine content (VLNC) cigarettes on smoking behavior, psychiatric symptoms and functioning, and acceptability and adverse outcomes in young adult smokers with ADHD. Participants will attend a screening session, 2 baseline sessions, 6 experimental sessions, and a 30 day follow-up visit. Participants will be asked to smoke only the study cigarettes that we provide for 6 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
71
Cigarettes containing a reduced amount of nicotine
Cigarettes containing a normal amount of nicotine
Duke University Medical Center
Durham, North Carolina, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Number of cigarettes smoked per day
Self-reported number of cigarettes smoked per day
Time frame: Six weeks
Composite measure of influence of reduced nicotine content on ADHD symptoms measured by ADHD Rating Scale and Clinical Global Impressions Scale along with related measures of cognition measured by the N-Back Task and the Continuous Performance Test
Composite of ADHD symptom questionnaires, inhibitory control, working memory
Time frame: Six weeks
Composite measure of outcomes associated with acceptability; withdrawal measured by the MNWS and compliance measured by Time-Line Follow-Back questionnaire and daily self-report cigarette use
Composite of study dropout, compliance, changes in physical health
Time frame: Six weeks
Measures of discomfort/dysfunction; withdrawal and depression
Withdrawal scale and depression measures
Time frame: Six weeks
Measures of other health-related behaviors; dependence measures
Drug and alcohol use questionnaires
Time frame: Six weeks
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