This study is designed to evaluate the surgeon's satisfaction with either deep or moderate neuromuscular blockade during laparoscopic gastrectomy surgery and observe the recovery profiles in the recovery room and the ward.The explorative objective of this study is to evaluate the safety profiles of deep and moderate neuromuscular blockades via observation of postoperative complications.
Neuromuscular blocking agents (NMBAs) are frequently using during anesthesia to facilitate tracheal intubation and to improve surgical conditions. In an adequately anesthetized and monitored patient, the presence of one or two responses in the train-of-four (TOF) pattern normally indicates sufficient relaxation for most surgical procedures in general practices. It has been called moderate neuromuscular blockade (mNMB) condition. Nowadays, laparoscopic surgeries have expanded impressively into various areas of surgeries, both in scope and volume. If any hypothetical advantages of deep neuromuscular blockade (dNMB) during laparoscopic surgery turned out to be realized in practice with sufficient supporting evidence, it would become an important anesthetic option for better patient outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
Continuous infusion of rocuronium for PTC 1 + Sugammadex
Intermittent injection of cis-atracurium for TOF 1 + Pyridostigmine \& Glycopyrrolate
Chonnam University Hwasun Hospital
Hwasun, South Korea
Surgical rating SCORE(SRS)
excellent (5), good but not optimal (4), moderate (3), poor but acceptable (2) or poor and unacceptable (1)
Time frame: every 15 minutes from the pneumoperitoneum, up to 120 minutes till the end of surgery
Respiratory rate
Respiratory rate of patient
Time frame: every 15 minutes from the arrival on the recovery room, up to 60 minutes
peripheral arterial oxygen saturation
peripheral arterial oxygen saturation(sPO2)
Time frame: every 15 minutes from the arrival on the recovery room, up to 60 minutes
visual analogue scale (VAS) for pain
visual analogue scale (VAS) for pain
Time frame: every 15 minutes from the arrival on the recovery room, up to 60 minutes
occurrence of nausea or vomiting
occurrence of nausea or vomiting with Rhodes Index
Time frame: every 15 minutes from the arrival on the recovery room, up to 60 minutes
the level of sedation or alertness
the level of sedation or alertness with OAA/S scale
Time frame: every 15 minutes from the arrival on the recovery room, up to 60 minutes
Postoperative Quality Recovery Scale (PQRS)
physiologic, nociceptive, emotive, cognitive and activities of daily living
Time frame: at baseline (the day before surgery), at 1 hour after surgery, at 6 hours after surgery, at 24 hours after surgery and at 7 days after surgery
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