The purpose of The Quatro Study is to assess the acceptability, preferences, user experience and effect on sexual behavior of four different vaginal microbicide or multi-purpose technology (MPT) delivery forms, using placebo products in 18-30 year old African women: rapidly disintegrating vaginal insert, intravaginal ring (IVR), film and gel. The study also examines adherence to the dosage forms through objective markers, developed for each dosage form prior to the commencement of the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
422
MatCH Research
Durban, South Africa
The University of Zimbabwe-University of California San Francisco Collaborative Research Program (UZ-UCSF)
Harare, Zimbabwe
Change from baseline in ratings and relative preference rankings of four vaginal delivery forms
Time frame: Baseline, Month 1, Month 2, Month 3, Month 4, Month 5
Attributes least and most favored for the vaginal delivery forms as measured by discreet choice experiment
Time frame: Month 5
Adherence assessed by self report via questionnaire
Time frame: Baseline, Month 1, Month 2, Month 3, Month 4, Month 5
Adherence assessed by objective biomarkers, utilizing antibodies, tagged recombinant proteins, biochemical assays and/or spectroscopy
Time frame: Baseline, Month 1, Month 2, Month 3, Month 4, Month 5
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.