AMENDTM Mitral Valve Repair System, Annuloplasty Ring Applied in a Transcatheter Method

Inclusion Criteria: * Patient age ≥18 * The patient requires mitral valve annuloplasty for mitral regurgitation without the need for concomitant cardiovascular surgical procedures * NYHA functional capacity ≥2 * The subject is high risk to undergo a mitral valve surgery as assessed by the center heart team * The patient is willing to comply with study procedures and is available to return to the implant center for follow-up visits. * The patient is willing to provide Informed consent Exclusion Criteria: * Cardiac or non-cardiac major or progressive disease, which in the investigator's discretion produces an unacceptable increased risk to the patient. * Life expectancy of less than twelve months. * Heavily calcified annulus or leaflets. * Previous or active endocarditis. * Active infection. * A previously implanted prosthetic mitral valve or annuloplasty ring/band. * The patient is contraindicated to general anesthesia. * Pregnant (urine HCG test result positive) or lactating patient. * Drug or alcohol abuse. * Participation in concomitant research studies of investigational products that will interfere with the study.