A Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum

Radboud University Medical Center34 enrolled

Overview

Live kidney transplantation is first choice for patients with end-stage kidney disease. Therefore, the safety and well-being of kidneys donors are highly important objectives in live kidney donation. Low pressure pneumoperitoneum can decrease postoperative pain and therefore also concomitant use of opioids.

However low pressure pneumoperitoneum can also decrease peri-operative conditions. In this trial the researchers will investigate whether peri-operative conditions during low pressure pneumoperitoneum can be optimized by the use of deep neuromuscular block.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Nephrostomy; Complications Pneumoperitoneum Observation of Neuromuscular Block

Interventions

Deep neuromsucular blockOTHER

Deep or standard neuromuscular block

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * obtained informed consent * age over 18 years Exclusion Criteria: * chronic use of analgesics or psychotropic drugs * use of non-steroidal anti-inflammatory drugs shorter than 5 days before surgery * known or suspect allergy to rocuronium or sugammadex * significant liver or renal dysfunction * pregnant or breastfeeding

Locations (1)

Radboud University Medical Center

Nijmegen, Netherlands

Outcomes

Primary Outcomes

Mean surgical rating score

Time frame: perioperative

Secondary Outcomes

Conversion to standard pressure pneumoperitoneum

Time frame: perioperative

Intra-operative complications

Time frame: perioperative

Length of pneumoperitoneum

Time frame: perioperative

Data from ClinicalTrials.gov

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