Gastric pH in Intubated Children - Part Two

University Children's Hospital, Zurich180 enrolled

Overview

Fasting (according to ASA, ESA or institutional guidelines) is an important strategy to minimize the risk of regurgitation, vomiting and pulmonary aspiration during general anaesthesia; the effect of fasting time for clear fluid on gastric pH in children is goal of this study and can be investigated in children undergoing elective procedures in general anaesthesia and intubation without inconvenience or additional invasive procedure and hence without additional risk Hypotheses: Gastric pH is higher in children that drink clear fluids until premedication before anaesthesia induction than in those that drink until 2 hours before anaesthesia induction

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

180

Conditions

Preoperative Fasting

Interventions

Eligibility

Sex: ALLMin age: 1 YearMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: age \> 1 / \< 16 years ASA class l or ll elective surgery requiring general anaesthesia using tracheal intubation Exclusion Criteria: disease or dysfunction of gastrointestinal tract chronic diseases or conditions not compatible with ASA class l or ll

Outcomes

Primary Outcomes

gastric pH

gastric pH is measured from gastric contents which is sampled in a syringe via an orogastric tube immediately during anaesthesia after tracheal intubation induction; suctioning of the stomach after intubation is a procedure routinely performed in every intubation child in our institution

Time frame: within 10 min after tracheal intubation

Secondary Outcomes

gastric aspirate volume

gastric aspirate volume is the amount of gastric contents which is sampled in a syringe via an orogastric tube immediately during anaesthesia after tracheal intubation induction; suctioning of the stomach after intubation is a procedure routinely performed in every intubation child in our institution

Time frame: within 10 min after tracheal intubation

subjective feeling of hunger/thirst

subjective feeling of hunger/thirst given as "yes" or "no" answer

Time frame: baseline

Postoperative Nausea and Vomiting (PONV) in recovery unit

Time frame: recovery period, on the average within 90 minutes after end of anaesthesia

Behaviour during recovery period

Rating Scale1-5 by blinded nurse (5: severely agitated/emergence delir with subsequent drug therapy, 4: agitated/emergence delir; 3: slightly agitated; 2: complaining pain but cooperative; 1: cooperative)

Time frame: recovery period, on the average within 90 minutes after end of anaesthesia

Behaviour during anaesthesia induction

Rating scale1-5 by (blinded) anaesthetist: 1: cooperating - 2: anxious but cooperating - 3: hostile - 4: crying - 5: agitated/fighting

Time frame: on the average within 20 minutes after arrival of patient in operating theatre

Nurse's Impression of patient's satisfactory

subjective feeling of the Nurse regarding patient's satisfactory given as rating scale from 1 to 4

Time frame: baseline

blood Ketone measurement

measurement of blood Ketone with a portable poc Ketone measurement device

Time frame: intraoperative