Metabolic Response to Fat and Glucose

Universität des Saarlandes60 enrolled

Overview

The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.

The metabolic response in plasma and urine, pre- and post-load tests in people with specific dietary lifestyles will be tested. This project will focus on fat and glucose induced changes of targeted metabolic pathways that have been related to diabetes and obesity risk.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

QUADRUPLE

Enrollment

Conditions

Obesity Insulin Resistance Healthy

Interventions

Glucose tolerance testOTHER

Standardized oral glucose tolerance test (75 g oral glucose) and blood collection before and 2hrs after the glucose load

Fat tolerance testOTHER

Oral fat tolerance will be provided to fasting participants and blood samples will be collected before and 4 hrs after the fat load.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * On a stable dietary habits Exclusion Criteria: * Pregnancy * Malabsorption disorders * Present or former cancer * Any oral medication that affect glucose or fat absorptions * Cholesterol lowering drugs (i.e. Statins) * other drugs: fibrates, MTX, or vitamin supplements * Diabetes (type 1 and type 2) * Alcoholism * Weight losing diet during the last 4 months * Liver diseases * Renal dysfunction * Gastric resection.

Locations (1)

University of Saarland

Homburg, Saarland, Germany