Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population. All Immunocompromised Non-HIV patients with respiratory failure were randomized into caspofungin and non-caspofungin group and corticosteroids and non-steroids group. The major outcome is 28 day mortality, the second outcome are time of respiratory rate decreases to less than 25 breath per minute, body temperature lower than 37.3℃.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
70mg ivdrip the first day, then 50mg ivdrip qd
40mg ivdrip q12h for 5 days 40mg ivdrip qd for 5 days 20mg po for 11 days
1.92g q8h
Beijing Chao Yang Hospital
Beijing, China
RECRUITINGmortality
Time frame: 28 days
Time for release of fever
Time for body temperature less than 37.3℃ for 48 hours
Time frame: 2 days
Time for release of respiratory distress
Time for respiratory rate \<25 breathes per minute for 48 hours
Time frame: 2 days
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