Prospective Cohort Study on the Efficacy of Vagus Nerve Stimulation for Children and Adolescents With Epilepsy(PVNS-CAE)

Inclusion Criteria: 1. age 4-18 2. Diagnostic criteria for epilepsia brain disorders 3. Having tried appropriate anti-epileptic drugs (AEDs) more than 1 year and zt least 6 seizures per month 4. patients or his(her) families could understand this method and sign the informed consent 5. Patients with good compliance and could complete postoperative follow-up Exclusion Criteria: 1. the vagus nerve lesion and damage 2. patients with progressive neurological diseases, cardiopulmonary anomaly, respiratory system diseases,digestive system diseases 3. patients'mental state is not stable， 4. patients with or anesthesia contraindications,such as long-term use of anticoagulation antiplatelet drugs etc. 5. patients have or need other implantable devices, such as pacemakers,defibrillators, cochlear and spinal nerve root stimulator. 6. patients due to their own reasons for the need for nuclear magnetic resonance imaging in the future clinical trials 7. patients have participated in other clinical trials.