Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients

Hospital de Clinicas de Porto Alegre93 enrolled

Overview

Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Mucociliary Clearance Defect Physical Disability

Interventions

Vibrocompression (VB)OTHER

Vibrocompression is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation (MV)

Hyperinflation (HMV)OTHER

Hyperinflation technique with mechanical ventilator which aims to clear the airways of patients on mechanical ventilation

HMV+VBOTHER

Association between Vibrocompression and Hyperinflation with mechanical ventilator

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * In mechanical ventilation for a period of 24-72 h * End-expiratory pressure (PEEP) lower 10 cm of water. * Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg. Exclusion Criteria: * Pneumothorax and hemothorax undrained * Subcutaneous emphysema * Osteoporosis * Acute respiratory distress syndrome - (ARDS) * Fractures of ribs * Obese ( BMI greater than 35) * Mechanical ventilator with higher peak pressures 40 cm of water.

Outcomes

Primary Outcomes

Weight in grams of the pulmonary secretions

Time frame: up to 24 weeks.

Secondary Outcomes

Time mechanical ventilator (MV) in days

Time frame: Through study completion, an average of 3 years.

Reintubation tracheal in percentage in the last 24 hours

Time frame: Through study completion, an average of 3 years.

Incidence of ventilator-associated pneumonia in percentage

Time frame: Through study completion, an average of 3 years.

Mortality in the MV in percentage

Time frame: Through study completion, an average of 3 years.

Heart Rate

Time frame: up to 24 weeks.

Respiratory frequency

Time frame: up to 24 weeks

Peripheral oxygen saturation in percentage

Time frame: up to 24 weeks

Tidal volume in milliliters

Time frame: up to 24 weeks

Peak inspiratory pressure in centimeters of water

Time frame: up to 24 weeks

Data from ClinicalTrials.gov

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