Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism

Shanghai 10th People's Hospital16 enrolled

Overview

Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism.

The effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism in patient with obesity and acanthuses nigrican.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acanthosis Nigricans Obesity

Interventions

melatoninDIETARY_SUPPLEMENT

Take one tablet (containing melatonin 3mg, calcium 52mg, vitamin B6 5mg) at bedtime everyday for 12 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age:18-60 years old; * BMI ≥ 28 kg/m2； * With acanthosis nigricans。 Exclusion Criteria: * With liver, kidney, gastrointestinal or other major organic serious diseases, cancer, lactating women, pregnancy.

Locations (1)

Shanghai Tenth People' Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

insulin resistance index

HOMA-IR:serum fasting insulin(mmol/L) × serum fasting glucose(mmol/L)/22.5

Time frame: 12 weeks

Secondary Outcomes

Blood pressure

Systolic blood pressure (mmHg) and diastolic blood pressure (mmHg)

Time frame: 12 weeks

Body weight

Body weight (kg)

Time frame: 12 weeks

Body fat

Body fat (%)

Time frame: 12 weeks

Neck circumference

Neck circumference (cm)

Time frame: 12 weeks

Waist circumference

Waist circumference (cm)

Time frame: 12 weeks

Total Cholesterol

Total Cholesterol (mmol/L)

Time frame: 12 weeks

Triglyceride

Triglyceride (mmol/L)

Time frame: 12 weeks

Low Density Lipoprotein

Low Density Lipoprotein (mmol/L)

Time frame: 12 weeks

High Density Lipoprotein

High Density Lipoprotein (mmol/L)

Data from ClinicalTrials.gov

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