A Sickle CEll Disease ComplicatioN Trial

Inclusion Criteria: Patients who meet all of the following criteria will be eligible to participate in the study: 1. 1\. Aged ≥ 5 years and ≤ 17 years at screening; 2. Has been diagnosed with SCD (that includes the genotypes HbSS, HbSC, and HbS/β°-thalassemia, documented by hemoglobin HPLC or electrophoresis); 3. Has had between ≥ 2 to ≤10 episodes of acute SCC (as defined above) within 12 months of the Screening Visit. At least one crisis must have been managed in a hospital, clinic, or emergency room. For at least 2 of the episodes, the site must obtain the documentation created in a medical record at the time of the event. 4. Must not be receiving HU or L-Glutamine, or if receiving HU and/or L-Glutamine must be at a stable weight-based treatment regimen (mg/kg), for at least 3 months prior to the Screening Visit with the intent to continue at a weight-based dose level at the discretion of the treating physician for the duration of the study, other than for safety reasons. If taking HU and/or L-glutamine, subjects must have had at least one SCC event (as previously defined) while on HU and/or L-Glutamine. 5. Has a parent or guardian who is able to give written informed consent, and the potential pediatric subject must be able to provide assent in a manner approved by the Institutional Review Board (IRB) and comply with the requirements of the study; and 6. If post pubertal in the opinion of the Investigator, must agree to use a reliable method of birth control (e.g., barrier, birth control pills, abstinence) during the study and for 1 month following the last dose of study drug. Exclusion Criteria Patients who meet any of the following criteria will be excluded from participation in the study: 1. A known allergy or hypersensitivity to fish or shellfish; 2. A known allergy or hypersensitivity to soy; 3. Inability to swallow capsules; 4. History of treatment with SC411; 5. Confirmed diagnosis of chronic pain or chronic opioid use: Defined as pain experienced ≥3 days per week over a 6-month period or daily opioid use for pain management; 6. Active infection with Human Immunodeficiency Virus (HIV), Hepatitis B, or Hepatitis C; 7. Prothrombin time \> 1.5 x ULN at screening; 8. Required regular anticoagulation or chronic aspirin therapy; 9. Moderate thrombocytopenia, defined as platelets \< 80,000/µL at screening; 10. History of stroke or Moyamoya syndrome; 11. Abnormal results on most recent transcranial Doppler (TCD) evaluation; 12. Received blood transfusion or blood products in the 2 months prior to the Screening Visit or on chronic blood transfusion; 13. Chronic renal insufficiency, defined as a eGFR \< 30ml/min at screening as estimated by the Schwartz equation (Appendix H), or requiring peritoneal or hemodialysis; 14. Abnormal liver function tests (ALT \> 3.0 x ULN) at screening; 15. Received any organ transplant; 16. Has a recent acute illness or other concomitant chronic medical or psychiatric condition that in the opinion of the Investigator would compromise participation in the study, prevent adherence to the protocol or confound the evaluation of the study outcome; 17. Is pregnant or lactating, or has the intention of becoming pregnant during the study (if a female of child-bearing potential or partner of a female of child-bearing potential and sexually active and not willing to use an effective means of birth control); 18. Is currently taking or has been treated with any form of omega-3 fatty acid or fish oil supplement within 30 days of the Screening Visit, or intends to do so during the course of the study; 19. Has been treated with any investigational product within 30 days of the Screening Visit or intends to receive an investigational product during the course of this study; and 20. There are factors that, in the judgment of the Investigator, would make it difficult for the patient to comply with the requirements of the study