A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism

Inclusion Criteria: * Clinical diagnosis of congenital hyperinsulinism * Duration of glucose levels less than 70mg/dL, by CGM, for an average of at least 120 minutes a day across baseline Days -3, -2, and -1 with no single duration less than 60 minutes on any of the baseline Days -3, -2, or -1, unless the subject received rescue treatment. * Can safely washout of background medications used to treat hyperinsulinism. Exclusion Criteria: * Use of any agent, such as diazoxide, octreotide, chronic systemic glucocorticoids, or β agonists that may affect glucose metabolism * Body Mass Index ≥ 35 kg/m2 * Pregnant females, females planning to become pregnant during the course of the study, females who have delivered 3 months before screening, or breastfeeding * Male subjects who are planning a pregnancy with a female partner during the course of the study or within 4 months after administration of study drug.