The Influences of Long Periods of Pneumoperitoneum and Head up Position on the Variation of Heart-rate Corrected QT Interval During Robotic-assisted Laparoscopic Gastrectomy - Observational Study

Yonsei University30 enrolled

Overview

Sympathetic activity could be increased during robot-assisted laparoscopic gastrectomy, which is performed in a head up position under CO2 pneumoperitoneum. Stimulation of the sympathetic nervous system prolongs the QT interval and can increases the susceptibility to life threatening cardiac arrhythmias. Thus the investigators decided to evaluate the heart-rate corrected QT interval (QTc interval) during robotic-assisted laparoscopic gastrectomy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stomach Cancer

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA class I-II 2. obtaining written informed consent from the patients who were undergoing robot- assisted laparoscopic gastrectomy. Exclusion Criteria: 1. emergency operation 2. cardiac disease (unstable angina, congestive heart failure, valvular heart disease) 3. ventricular conduction abnormality 4. prior pacemaker insertion 5. abnormal electrolyte values 6. patients who take antiarrythmic agent 7. hepatic or renal failure 8. drug hyperactivity 9. neurological or psychiatric illnesses

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Evaluate the heart-rate corrected QT (QTc) interval (msec) during robotic-assisted laparoscopic gastrectomy

(T0: Pre-induction T1: 10min after anesthetic induction T2: 1min after CO2 pneumoperitoneum T3: 5min after CO2 pneumoperitoneum T4: 30min after steep trendelenburg position T5:60min after steep trendelenburg T6: 90min after steep trendelenburg T7: Supine positon following end of pneumoperitoneum T8: 5 min after end of pneumoperitoneum T9: End of surgery T10: 10min after extubation)

Time frame: through study completion, an average of 5 hours