Dermatopharmacokinetic Trial of LEO 80185 Gel

Inclusion Criteria: 1. Signed and dated informed consent form has been obtained. 2. Healthy Japanese male subjects according to medical history, physical examination, ECG, vital signs and laboratory tests. 3. Aged 20 to 40 years inclusive. 4. Subjects with enough skin area for application of the investigational products. Exclusion Criteria: 1. Body Mass Index outside the range 18-25 kg/m² 2. History or presence of alcohol or drug abuse. 3. History of allergic reaction to any medications. 4. Subjects with, or with a history of, systemic or cutaneous disease that could in any way confound interpretation of the trial results (e.g. atopic dermatitis, eczema, psoriasis) 5. Known or suspected hypersensitivity to any component of LEO 80185 gel or Dovobet® ointment. 6. Known or suspected hepatic, renal or cardiac disorders. 7. Known or suspected disorders of calcium metabolism associated with hypercalcaemia or albumin-corrected serum calcium above the reference range from the sample taken during screening. 8. Subjects with any of the following skin diseases/skin abnormalities that impede the assessment of the application site (back): * eczema/dermatitis or abnormal pigmentation * bruises or scars * inflammation due to sunburn * history and/or presence of skin allergy such as atopic dermatitis * history of drug hypersensitivity * Signs of skin irritation/disease/disorders/symptoms or blemishes at the planned site of application (e.g. erythema, dryness, roughness, scaling, scars, moles, sunburn) 9. Subjects suspected of infection based on the infection testing results from the sample taken during screening (Hepatitis B surface antigen, HCV antibiody, HIV antigen/antibody, serological test for syphilis). 10. Use of systemic, locally injected or inhaled corticosteroids within 4 weeks of Day 1. 11. Use of vitamin D or calcium supplements, or systemic vitamin D analogues within 4 weeks of Day 1. 12. Use of any medication (systemic or topical) within 2 weeks of Day 1. 13. Subjects who have received treatment with any non-marketed drug substance (i.e. an agent which has not yet been made available for clinical use following registration) within 4 months of Day 1. 14. Current participation in any other interventional clinical trial. 15. Previously randomised in this clinical trial. 16. Previous or current photo-induced or photo-aggravated disease (e.g. abnormal response to sunlight). 17. Exposure to excessive or chronic ultraviolet radiation (e.g. sunlight, sun lamps, tanning booths or photo-therapy) within 4 weeks of Day 1. 18. In the opinion of the (sub)investigator, participation in the trial is inappropriate.