Gestational trophoblastic neoplasm affect women and is sensitive to chemotherapy especially methotrexate and the investigators try to find a role of surgery plus methotrexate instead of multiple doses and cycles of chemotherapy.
Gestational trophoblastic neoplasm affect women and is sensitive to chemotherapy espechialy methotrexate and the investigators try to find a role of surgery plus mehotrexate instead of multiple doses and cycles of chemotherapy that affect the patient quality of life and complication related to both line of management and time of decrease of B-hcg.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
After written consent laparotomy will be done then pelvic examination for extra uterine spread, palpation of liver, omentum for any gross lesions and then hystrectomt bilateral salpigooophrectomy will be done) plus single course methotrexate(anti folate chemotheraputic agent, vial form given by intramuscular injection) 1mg/kg every other day alternating with calcium folinate 0.1 mg/kg for 4 doses each cycle then measuring B-HCG (the cycle may be repeated until normalization of B-HCG)
methotrxate 1mg/kg every other day alternating with calcium folinate 0.1 mg/kg for 4 doses each cycle then measuring B-HCG and cycle repeated until normalization of B-HCG
Mansoura University Hospital
Al Mansurah, Dakahlia Governorate, Egypt
RECRUITINGMaher Elesawi Kamel Elesawi
Mīt Ghamr, Eldakahlia, Egypt
RECRUITINGnumber of primary chemotherapy courses till B-hCG reach less than 5 MU/ML
Time frame: 1-6 months
quality of life( questionairre)
pain scale from zero to 11, return to ordinary activities
Time frame: 1-6 months
complications from management
renal, hepatic impairments, anemia,
Time frame: 1-6 months
time interval for B-hCG reach less than 5 MU/ML
the time taken for B-hCG to reach below 5 MU/ML
Time frame: 1-6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.