"Novo C Plus" Vitamin C Containing Dietary Supplement Bioavailability in Healthy Subjects

Inclusion Criteria: * 21-65 years old healthy volunteers * body weight \>45 kg * body height \>150 cm * plasma ascorbic acid at screening \<75 µmol/l * signed written informed consent * subject agrees avoid vitamin C containing medications and dietary supplements from screening until V0 visit (maximum 15 days) * subject agrees to avoid high activity physical exercise 72 hours prior to V0 visit Exclusion Criteria: * confirmed or suspected active infection * liver or renal failure (equal or greater than CKD3) * chronic disease that affects absorption or vitamin C metabolism * severe metabolic disorder * body mass index \>35 kg/m2 * malabsorption syndrome that affects vitamin C metabolism * heart failure, angina pectoris, ventricular arrhythmias or atrial fibrillation with \>100/min ventricular rate * gastrointestinal bleeding in past three months * uncontrolled diabetes mellitus (HbA1c\>8,5%) * malignant disease * alcohol or drug abuse * active psychiatric disorder, intention for suicidal, disorders with unconsciousness * psychopathic disorder, lack of cooperation * known coagulopathy * chronic obstructive lung disease or active smoking (more than 2 cigarettes in the past 6 months) * untreated hypertension if blood pressure is greater than 165/95 mmHg * gravidity or breastfeeding * taking more than 100 mg vitamin C daily within 2 weeks to screening