Regulation of Intestinal and Hepatic Lipoprotein Particle Production by Blood Glucose in Humans

Inclusion Criteria: 1. Men and women, aged 18 to 60 years 2. Body mass index 20 kg/m2 to 27 kg/m2 3. Hemoglobin above 130g/L 4. Normal glucose tolerance in response to a 75g, 2-hr OGTT Exclusion Criteria: 1. Subject has a history of hepatitis/hepatic disease that has been active within the previous two years. 2. Any subject with active bleeding, bleeding diathesis, clotting abnormalities or recent surgery (within past 1 month) 3. Any significant active (over the past 12 months) disease of the gastrointestinal, pulmonary, neurological, renal (Cr \> 1.5 mg/dL), genitourinary, hematological systems, or has severe uncontrolled treated or untreated hypertension (sitting diastolic BP \> 100 or systolic \> 180). 4. History of diabetes or OGTT indicative of diabetes or impaired glucose tolerance. 5. Any history of a MI or clinically significant, active, cardiovascular history including a history of arrhythmia's or conduction delays on ECG, unstable angina, or decompensated heart failure. 6. Any laboratory values: AST \> 2x ULN; ALT \> 2x ULN TSH \> 6 mU/l 7. Current addiction to alcohol or substances of abuse as determined by the investigator. 8. Mental incapacity, unwillingness or language barrier precluding adequate understanding or cooperation 9. Taking any prescription or non-prescription medications at the time of the study 10. Having donated blood three months prior to and three months post study procedures 11. A pregnancy test will be performed 1 to 3 days prior to each study in all female subjects. Those who test positive for pregnancy will be excluded. 12. Known allergy, hypersensitivity or contraindication to receiving study medications.