Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)

Inclusion Criteria: 1. Patient with no evidence of any invasive tumor mass at inclusion (clinical and, if any, radiological exams) 2. Carriers of known germline BRCA1 deleterious mutation (a personal history of cancer is NOT mandatory). 3. Age ≥ 30 years for patient with personal previous history of cancer 4. Age ≥ 40 years for patient without personal previous history of cancer 5. Patient who a follow-up visit is scheduled in the including center at least once a year 6. Patient having health care insurance 7. Signed informed consent by patient Exclusion Criteria: 1. Patient presenting with invasive tumor masses (e.g. stage IV cancer or localized cancer not yet surgically removed) 2. Carriers of germline BRCA1 variant of unknown significance 3. Carriers of germline BRCA2 deleterious mutation or variant 4. Individuals with a low risk of BRCA1-related tumor growth, i.e. women who underwent prophylactic bilateral mastectomy AND adnexectomy. 5. Any medical or other condition that in the Investigator's opinion rendered the patient unsuitable for this study 6. Patient deprived from ability to decide on her own. 7. Patient unable to have a regular follow up for geographical, social or psychological reasons.