HFS-guided Renal Ablation for Improving Outcome of Renal Denervation Procedure

Inclusion Criteria: * Office-based systolic blood pressure of ≥140/90 mm Hg and \<160/100 mm Hg (moderate resistant hypertension) or ≥160/100 mm Hg (severe resistant hypertension), despite treatment with 3 antihypertensive drugs (including a diuretic). * A glomerular filtration rate ≥45 mL/min/1⋅73 m2, with modification of diet using a renal disease formula. Exclusion Criteria: * Secondary causes of hypertension * Severe renal artery stenosis or dual renal arteries * Congestive heart failure * Left ventricular ejection fraction \<35% * Previous renal artery stenting or angioplasty * Type 1 diabetes mellitus