Prediabetes, defined by either impaired fasting glucose and/or impaired glucose tolerance, is a known high-risk condition predisposing to future diabetes mellitus type 2. Strategies to prevent progression from prediabetes to diabetes have been widely studied, however, without striking long-term effects of any kind of intervention (pharmacological, behavioral...). The investigators therefore investigate certain nutritional approaches concerning nutrient content and favorable food components, targeting metabolic improvement.
Prediabetes, defined by either impaired fasting glucose and/or impaired glucose tolerance, is a known high-risk condition predisposing to future diabetes mellitus type 2. Strategies to prevent progression from prediabetes to diabetes have been widely studied, however, without striking long-term effects of any kind of intervention (pharmacological, behavioral...). The investigators therefore investigate certain nutritional approaches concerning nutrient content and favorable food components, targeting metabolic improvement. The main comparison will assess differences in metabolic outcome due to low-carb or low-fat dietary intervention in short- and long-term design. Additionally, the role of PUFA will be assessed during long-term intervention to achieve better maintenance of metabolic improvements from the first study phase.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
250
dietary consulting implies specific dietary advice based on pre-interventional self-report regarding food intake; consulting focuses on nutrient content, calory intake, weight loss; with regard to randomisation consulting intensity and content varies
German Institut for Human Nutrition; Department for Clinical Nutrition
Bergholz-Rehbrücke, Brandenburg, Germany
RECRUITINGGerman Institute for Human Nutrition, Department for Clinical Nutrition
Berlin, Germany
RECRUITINGchange in postprandial glycaemia (2h plasma glucose level of the 75 g oral glucose tolerance test (OGTT))
Time frame: 3 weeks, 6 months, 1 year, 3 years
change in hepatic fat content confirmed by proton magnetic resonance spectroscopy by 3 T MR imaging
Time frame: 3 weeks, 6 months, 1 year, 3 years
change in insulin sensitivity confirmed by 75 g oral glucose tolerance test (OGTT)
insulin resistance is calculated as follows: Insulinogenic index (IGI) = (I30 - I0) / (G30 - G0) ISIest= 10000/²√ ((G0 x I0) x ((G0+G30+G60+G90+G120)/5) x ((I0+I30+I60+I90+I120)/5))
Time frame: 3 weeks, 6 months, 1 year, 3 years
change in insulin secretion confirmed by 75 g oral glucose tolerance test (OGTT)
insulin resistance is calculated as follows: Insulinogenic index (IGI) = (I30 - I0) / (G30 - G0) ISIest= 10000/²√ ((G0 x I0) x ((G0+G30+G60+G90+G120)/5) x ((I0+I30+I60+I90+I120)/5))
Time frame: 3 weeks, 6 months, 1 year, 3 years
change in distribution of body fat confirmed by MR-Imaging by 3 T whole body imager
Time frame: 3 weeks, 6 months, 1 year, 3 years
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