This study evaluates whether ALA intake alters total cholesterol and homeostatic factors and the relationship between these alteration and lipoprotein associated phospholipase A2 (Lp-PLA2) activity.
An 8-week, randomized, double-blind, placebo-controlled study was conducted with 86 nondiabetic and borderline-to-moderate hypercholesterolemic (200mg/dL ≤ serum cholesterol ≤ 300mg/dL) subjects, not taking any medications and supplements to affect lipid metabolism, platelet function and inflammation, divided into two groups: an α-linolenic acid (ALA) group \[1.2 g (two capsules) of perilla oil daily; 497 mg ALA\] and a placebo group (1.2 g of medium-chain triglyceride oil daily).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
86
Yonsei University
Seoul, South Korea
Collagen-Epinephrine Closure Time (C-EPI CT)
Time frame: Baseline
Collagen-Epinephrine Closure Time (C-EPI CT)
Time frame: 8-week follow up
Prothrombin Time (PT)
Time frame: Baseline
Prothrombin Time (PT)
Time frame: 8-week follow up
Activated partial thromboplastin time (aPTT)
Time frame: Baseline
Activated partial thromboplastin time (aPTT)
Time frame: 8-week follow up
Fibrinogen
Time frame: Baseline
Fibrinogen
Time frame: 8-week follow up
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