The purpose of this study is to investigate the pharmacokinetic properties in critically ill patients of a few of the most used antimicrobial drugs (amikacin, linezolid, meropenem, piperacillin/tazobactam, vancomycin). The primary objective is the identification of the clinical parameters affecting the kinetics of these drugs and the study of the contribution of extracorporeal depuration techniques to the elimination of these molecules. The secondary objective is to describe and compare the therapeutic therapies adopted in the Intensive Care Units participating in the project. For each molecule, the study will involve 300 patients admitted to Intensive Care Units. For each patient five blood samples will be collected on average, in order to measure drug plasma concentrations. Patient clinical conditions will be collected through an electronic clinical record. Finally, on the basis of those data, pharmacokinetic models will be developed to describe the evolution in time of drug plasma concentrations.
Study Type
OBSERVATIONAL
Enrollment
1,500
Drug choice is performed according to standard clinical practice, that will not be modified by the participation in the study. As a consequence, assignment of patients to groups is not protocol based, but it is defined by standard clinical choices.
Drug choice is performed according to standard clinical practice, that will not be modified by the participation in the study. As a consequence, assignment of patients to groups is not protocol based, but it is defined by standard clinical choices.
Drug choice is performed according to standard clinical practice, that will not be modified by the participation in the study. As a consequence, assignment of patients to groups is not protocol based, but it is defined by standard clinical choices.
Drug choice is performed according to standard clinical practice, that will not be modified by the participation in the study. As a consequence, assignment of patients to groups is not protocol based, but it is defined by standard clinical choices.
Ospedale Maurizio Bufalini, UO Anestesia Terapia Intensiva
Cesena, Emilia-Romagna, Italy
Ospedale S. Giovanni di Dio ASL 10, Servizio Anestesia e Rianimazione
Florence, FI, Italy
Ospedale San Giovanni di Dio
Orbetello, Grosseto, Italy
Presidio Ospedaliero "San Leopoldo Mandic"
Merate, Lecco, Italy
Ospedale A. Manzoni, U.O. Anestesia e Rianimazione 1
Lecco, Lombardy, Italy
Ospedale San Giovanni Bosco, Servizio Anestesia e Rianimazione B-DEA
Turin, Piedmont, Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, PV, Italy
Ospedale del Mugello
Borgo San Lorenzo, Tuscany, Italy
Ospedale Santa Maria Nuova, Anestesia e Rianimazione
Florence, Tuscany, Italy
Ospedale Maggiore, C.A. Pizzardi
Bologna, Italy
...and 1 more locations
Drug plasma concentration (time-dependent antibiotics)
Time frame: 30 min after first dose; 1 day after first dose; 2 day after first dose; 2 measures between the 3rd and the 8th day of treatment
Drug plasma concentration (concentration-dependent antibiotics)
Time frame: 30 min after first dose; immediately before second dose; peak and trough of the same dose in the 2nd day of therapy; peak and trough of the same dose between the 3rd and the 5th day of therapy
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