A Study to Evaluate Efficacy and Safety of QPI-1002 for Prevention of Acute Kidney Injury Following Cardiac Surgery

Inclusion Criteria: * Have the ability to understand the requirements of the study, are able to provide written informed consent and are willing and able to comply with the requirements of the study * Male or female, age ≥ 45 years old. * Have stable renal function per Investigator assessment and no known increase in serum creatinine of ≥ 0.3 mg/dL during preceding 4 weeks. * Scheduled to undergo non-emergent open chest cavity cardiovascular surgeries, including use of coronary pulmonary bypass (CPB) and no CPB: * Combined coronary artery bypass grafting (CABG) surgery and surgery of one or more cardiac valve (valve(s) surgery) and at least 1 AKI Risk Factor; * Surgery of more than one cardiac valve (valve surgery) and at least 1 AKI Risk Factor; * Surgery of the aortic root or ascending part of the aorta, or in combination with the aortic valve, and at least 1 AKI Risk Factor; circulatory arrest is not excluded; * Aortic root or ascending part of the aorta, combined with CABG and/or valve(s) surgery and at least 1 AKI Risk Factor; circulatory arrest is not excluded; * If only CABG or single valve surgery, subjects are required to have at least 2 AKI Risk Factors: AKI Risk Factors: * Age ≥ 70 years * eGFR ≤ 60 ml/min/1.73m2 by CKD-EPI formula at Screening. * Diabetes (Type 1 or 2), requiring at least 1 oral hypoglycemic agent or insulin * Proteinuria ≥ 0.3g/d, spot UPCR ≥ 0.3g/gm or urine dip stick ≥ +2 * History of congestive heart failure requiring hospitalization Exclusion Criteria: * Have an eGFR ≤ 20 mL/min/1.73 m2 * Subjects with an eGFR ≤ 60 mL/min/1.73 m2 requiring intravascular iodinated contrast within 48 hours of the day of surgery. However, subjects may be included if the post contrast increase in serum creatinine is \< 0.3 mg/dl in at least 2 serum creatinine evaluations performed not less than 36 hours apart. * Have a history of any organ or cellular transplant which requires active immunosuppressive treatment which can interfere with kidney function * Emergent surgeries, including aortic dissection, and major congenital heart defects * Scheduled to undergo transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR) or single vessel, mid-CAB off-pump surgeries or left ventricular assist device (LVAD) implantation * Have participated in an investigational drug study in the last 30 days * Have a known allergy to or had participated in a prior study with siRNA * Have a history of human immunodeficiency virus (HIV) infection * Have known active Hepatitis B (HBV) (Note: Subjects with a serological profile suggestive of clearance, or prior antiviral treatment of HBV infection may be enrolled) * Are HCV-positive (detectable HCV RNA) (Note: Subjects at least 24 weeks from completion of treatment with an antiviral regimen and who remain free of HCV as determined by HCV RNA testing may be enrolled.) * Have had cardiogenic shock or hemodynamic instability within the 24 hours prior to surgery, requiring inotropes or vasopressors or other mechanical devices such as intra-aortic balloon counter-pulsation (IABP) * Have required any of the following within a week prior to cardiac surgery: defibrillator or permanent pacemaker, mechanical ventilation, IABP, left ventricular assist device (LVAD), other forms of mechanical circulatory support (MCS) (Note: The prophylactic insertion of an IABP preoperatively for reasons not related to existing LV pump function is not exclusionary). * Have required cardiopulmonary resuscitation within 14 days prior to cardiac surgery * Have ongoing sepsis or history of sepsis within the past 2 weeks or untreated diagnosed infection prior to Screening visit. Sepsis is defined as presence of a confirmed pathogen, along with fever or hypothermia, and hypoperfusion or hypotension * Have total bilirubin or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 2 times the upper limit of normal (ULN) at time of screening * Have Child Pugh Class A liver disease with ALT/AST above the upper limit of normal or Class B or higher. (This criterion is only applicable in a patient population with underlying chronic liver disease, i.e., cirrhosis.)