Cryoprobe Transbronchial Lung Biospy in Patients With Mechanical Ventilation

Inclusion Criteria: * ≥18 years old * Patients with mechanical ventilation. * Patients with diffuse lung disease of unknown etiology. * Need for confirming/excluding a diagnosis, with therapeutical and prognosis implications. * Inform consent signed by family. Exclusion Criteria: * Use of anticoagulant therapy or presence of a coagulation disorder (abnormal platelets counts, international normalized ratio \> 1.5). * Comorbidities that could increase the risk of the TBLB. * Bullous emphysema. * Hemoptysis, pneumothorax. * Severe respiratory insufficiency requiring PEEP \>12 cm H2O