A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy

Inclusion Criteria: 1. NICHD Neonatal Research Network Hypothermia Trial inclusion criteria 2. Mothers must have consented or given verbal assent for cord blood collection at delivery, and cord blood must be available for volume and red blood cell reduction before 45 hours of age 3. The infant must be able to receive at least one dose of autologous cord blood before 48 hours of age 4. All infants must have signs of encephalopathy within 6 hours of age Exclusion Criteria: 1. Major congenital or chromosomal abnormalities 2. Severe growth restriction (birth weight \<1800 g) 3. Opinion by attending neonatologist that the study may interfere with treatment or safety of subject 4. Moribund neonates for whom no further treatment is planned 5. Infants born to mothers are known to be HIV, Hepatitis B, Hepatitis C or who have active syphilis or CMV infection in pregnancy 6. Infants suspected of overwhelming sepsis 7. ECMO initiated or likely in the first 48 hours of life