Study of SNX-5422 in TP53 Null Cancers

Inclusion Criteria: * Confirmed solid or hematological TP53 null type cancer. * No more than 4 prior lines of systemic anti-cancer therapy. * Males or non-pregnant, non-breastfeeding females 18 years-of-age or older. * Karnofsky performance score 60 * Life expectancy of at least 3 months. * Adequate baseline laboratory assessments * Recovered from toxicities of previous anticancer therapy to CTCAE Grade ≤ 1 with the exception of alopecia. Exclusion Criteria: * Treatment with an investigational agent within 30 days prior to the first dose of SNX-5422 or planning to receive an investigational agent during the study. * Treatment with other anticancer drugs within 28 days or 5 half-lives of anticancer therapy (whichever is shorter) is prohibited from 30 days prior to the first dose of SNX-5422 and throughout the study. * Radiation treatment within 2 weeks. * The need for treatment with medications with clinically relevant metabolism by the cytochrome P450 (CYP) 3A4 isoenzyme within 3 hours before or after administration of SNX-5422 (Appendix B). * Appropriately corrected screening ECG QTc interval 470 msec for females, 450 msec for males. * Currently receiving medications known to cause QT prolongation AND corrected QTc of 450 msec for females, 430 msec for males. * Patients with chronic diarrhea of grade 2 or greater despite maximal medical management. * Gastrointestinal diseases or conditions that could affect drug absorption, including gastric bypass. * Gastrointestinal diseases that could alter the assessment of safety, including irritable bowel syndrome, ulcerative colitis, Crohn's disease, or hemorrhagic coloproctitis. * History of documented adrenal dysfunction not due to malignancy. * Seropositive for human immunodeficiency virus (HIV) or hepatitis C virus (HCV). * History of chronic liver disease. * Active hepatitis A or B. * Current alcohol dependence or drug abuse. * Clinically significant glaucoma, retinitis pigmentosa, or macular degeneration. * Other serious concurrent illness or medical condition.