Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate

Inclusion Criteria: 1. Patients with systolic blood pressure between 140-179mmHg and/or diastolic blood pressure between 90-109mmHg. 2. Aged between 18-65 years old. 3. Signed informed consent. Exclusion Criteria: 1. Secondary hypertension 2. Patients who taking amiodarone over 200mg/day to control arrhythmia 3. Patients who taking class I antiarrhythmic drugs 4. Resting heart rate less than 60bpm 5. Serious liver and kidney disease: aspartate aminotransferase (AST) or alanine aminotransferase) (ALT)\>2.5 times upper limit of normal; serum creatinine\>3mg/dl (265umol/L) 6. Severe heart failure: New York Heart Association (NYHA) functional class 2, 3, 4 7. Myocardial infarction or stroke in the last three months. Unstable angina pectoris in the last month. 8. Patients with asthma or chronic obstructive pulmonary disease. 9. Pregnancy and breast-feeding 10. Patients allergy to investigational drugs or have contraindication to investigational drugs. 11. Others unsuitable to participate in the study judged by investigator.