The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients.
Recent studies suggest that early goal directed sedation might improve the outcome of critically ill patients. The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients with relative stable hemodynamics.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
25
Dexmedetomidine or control drug for sedation * Analgesia * Propofol at lowest dosage. * Dose range: 0.1- 0.7 u/kg/hour * Target RASS score of -2 to +1 * Supplemental other sedatives at lowest effective dose
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China
RECRUITINGMicrocirculatory function as assessed by perfused vessel density
Microcirculatory parameter
Time frame: one hour
Dose of sedatives and analgesic agents
Time frame: 14 days
Oxygen metabolic: lactate clearance time
Time frame: six hours
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